The enhanced tyrosinase inhibition rate (up to 50.02 ± 0.76% at 100 μg/mL) and xanthine oxidase inhibition rate (34.04 ± 1.43%) in fermented A. argyi leaves make solid-state fermented leaves potential candidates against cosmetic/dermatological and hyperuricemia-related applications, respectively. The gene discussed is TYR; the disease is hyperuricemia.