This latter triggers systemic inflammatory responses marked by the secretion of pro-inflammatory cytokines, including IL-6, IL-8, and TNF-α, which induce endothelial activation, neutrophil infiltration, and capillary permeability, thereby increasing the risk of complications such as systemic inflammatory response syndrome (SIRS), multiorgan failure, and ARDS [57]. The gene discussed is CXCL8; the disease is systemic inflammatory response syndrome.