Cholelithiasis occurred significantly less frequently among GLP/GIP users (3.5%) compared with non-users (6.3%), corresponding to a risk ratio (RR) of 1.811 (95% CI: 1.636–2.004) and a hazard ratio (HR) of 1.269 (95% CI: 1.140–1.413; p < 0.001). Here, GIP is linked to cholelithiasis.