Deaths of any cause (the primary endpoint) occurred in 477 patients (38%): 291 patients (35.7%) without DM, 111 diabetic patients (49.5%) on oral antidiabetic drugs and 75 diabetic patients (70.0%) on insulin therapy (hazard ratio [HR] = 1.57, 95% confidence interval [1.26–1.96] for the group with DM on oral antidiabetic drugs vs. the group without DM; HR = 2.80 [2.17–3.61] for the group with DM on insulin therapy vs. the group without DM and HR = 1.78 [1.33–2.39] for the group with DM on insulin therapy vs. the group with DM on oral antidiabetic drugs; Table 3 and Figure 1). This evidence concerns the gene INS and diabetes mellitus.