ANGPT1 and adenomyosis: qRT-PCR analysis demonstrated that LNG-IUS treatment significantly reduced the mRNA expression of all three angiogenic factors in the eutopic endometrium compared with untreated adenomyosis (ANGPT1 mRNA: p = 0.015; ANGPT2 mRNA: p = 0.019; VEGFA mRNA: p = 0.028, Figure 4A–C).