To confirm the histopathological diagnosis and to rule out a high grade endometrial stromal sarcoma, an immunohistochemical examination was performed, evaluating the following markers: WT1 (Figure 5a), CD10 (Figure 5b), over-expression pattern for p53 (intense and diffuse nuclear staining) in 80% of tumor cells (Figure 5c), absence of immunostaining for cyclin D1 (Figure 5d). This evidence concerns the gene TP53 and neoplasm.