Representative brain MRI images (Figure 2 and Figure 3) were included to illustrate the characteristic neurodegenerative pattern observed in Wolfram syndrome, notably pontine atrophy and supratentorial white-matter abnormalities, which align with the clinical phenotype and previously described neuroanatomical vulnerabilities in WFS1-related disease [7,8,9,10]. The gene discussed is WFS1; the disease is Wolfram syndrome.