Motor coordination phenotypes (dysmetria, ataxia, adiadochokinesia, and tandem gait impairment) showed particularly strong dependence on protein-class variables, which aligns with the high vulnerability of cerebellar and cerebello-thalamo-cortical systems to disturbances in ER stress regulation and calcium homeostasis—core functions of wolframin. The gene discussed is WFS1; the disease is cerebellar ataxia.