Gain-of-function mutations in the NLRP3 gene cause the CAPS spectrum, which includes FCAS (OMIM 120100), Muckle–Wells syndrome (MWS, OMIM 191900), and neonatal-onset multisystem inflammatory disease (NOMID, OMIM 607115). This evidence concerns the gene NLRP3 and familial cold autoinflammatory syndrome.