Therefore, this study aims to investigate the potential association between MMP2 promoter SNPs (−1575G/A (rs243866), −1306C/T (rs243865), and −790T/G (rs243864)) and CP onset, comorbidities, and neurodiagnostics in children with a history of perinatal asphyxia. Here, MMP2 is linked to asphyxia.