Notably, ASPM expression levels are closely associated with the development of digestive system tumors such as cholangio carcinoma, esophageal cancer, and pancreatic ductal adenocarcinoma [68,69,70], and its potential as a cross-cancer prognostic marker has been validated in multi-tumor species such as bladder cancer and renal cancer [71,72,73,74]. Here, ASPM is linked to neoplasm.