Mechanistic studies have elucidated distinct oncogenic roles: (i) CAMSAP2 stabilizes non-centrosomal microtubules to facilitate hepatocellular carcinoma metastasis; (ii) γ-TuRC constitutive activation enhances centrosomal nucleation efficiency, potentiating invasive phenotypes; (iii) ASPM orchestrates oncogenic signaling via canonical Wnt/β-catenin pathway activation, driving solid tumor progression. Here, CAMSAP2 is linked to hepatocellular carcinoma.