Her medical history included estrogen-receptor-positive breast cancer (treated in 2007 with quadrantectomy, axillary lymphadenectomy, adjuvant chemotherapy, and radiotherapy), thyroid nodules, chronic obstructive pulmonary disease (COPD), tricuspid valve insufficiency, dyslipidemia, arterial hypertension, anxiety-depressive disorder, colonic diverticulosis, and colitis. Here, ESR1 is linked to chronic obstructive pulmonary disease.