A 60-year-old Caucasian male was diagnosed with CML Ph+, e14a2 BCR::ABL1 transcript, intermediate prognostic risk according to Sokal (0.88) and low ELTS score (1.0188), in July 2021, at the age of 58. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.