Additionally, the bacteriocin it secretes (e.g., lactocin Johnsonii) can activate naive macrophages to differentiate into CD206+ macrophages and induce the release of IL-10 via the TLR1/2-STAT3 pathway [60], alleviating experimental colitis and further enhancing anti-inflammatory and probiotic effects. This evidence concerns the gene TLR1 and colitis.