The known functions of B7-H3 include the inhibition of the proliferation of antitumor T cells, such as CD8+ T cells, CD4+ T cells, Th1 cells, and Th2 cells; the mediation of the polarization of TAMs towards the M2 phenotype, which is favorable for tumor growth; and the inhibition of the activation of NK cells, amongst others [21]. This evidence concerns the gene CD4 and neoplasm.