The enrichment results revealed significant associations with 31 KEGG pathway terms and 62 GO terms (corrected p < 0.05), including metabolic pathways, Apelin signaling pathway, cGMP-PKG signaling pathway, linoleic acid metabolism, and Cushing syndrome (Figure 3C and Table S7). Here, APLN is linked to Cushing syndrome due to macronodular adrenal hyperplasia.