S100A4 and asthma: The top upregulated genes in cluster 14, namely, VIM, TYROBP, FCER1G, LYZ, and S100A4, in contrast, was selectively enriched for asthma-related pathways, including “immune response” (adjusted p = 5.94 × 10−35), “defense response” (adjusted p = 8.97 × 10−39), and “regulation of immune system process” (adjusted p = 1.23 × 10−31) (Figure 2g,h).