For its role as a tumor suppressor and for its involvement in epithelial–mesenchymal transition (EMT)—in which the relationship with SOX2 can influence the proliferation and progression of different cancers—we decided to focus on SOX2/SOX17 balance to verify if it can determine a differentiation process in ATC cells [38,39,40,41,42]. This evidence concerns the gene SOX2 and neoplasm.