Notably, alongside the existing data suggesting that IL-10 regulates intercellular interactions within the CNS and immune system, there is a growing body of research indicating impaired IL-10 production or signaling in patients and animals with various neurological diseases, including neuropathic pain, multiple sclerosis, Alzheimer’s disease and Parkinson’s disease [255,258,259,260,261,262]. Here, IL10 is linked to early-onset autosomal dominant Alzheimer disease.