The negative effect of IL-10 on Alzheimer’s disease was confirmed by the observation that the absence of IL-10 in transgenic mice with cerebral amyloidosis resulted in Aβ being phagocytized by activated microglia, leading to a reduction in Aβ levels in the mice’s brains and ultimately alleviating the disease’s symptoms to some extent [268]. This evidence concerns the gene IL10 and early-onset autosomal dominant Alzheimer disease.