In the context of HIV infection, three key death receptor-mediated sequences of events occur, such as the Fas/FasL, TNF-related apoptosis-inducing ligand (TRAIL), and tumor necrosis factor-alpha (TNF-α), which have been implicated in the induction of CD4+ T-cell apoptosis and immune system dysregulation. This evidence concerns the gene TNFSF10 and HIV infectious disease.