Notably, Yang et al. demonstrated that Saccharina japonica fucoidan treatment in ROT-induced PD mice significantly reduced serum levels of LPS, TNF-α, and IL-1β, and decreased the expression of TLR4 and NF-κB in key PD-affected regions (substantia nigra, striatum, and colon) [25]. This evidence concerns the gene NFKB1 and Parkinson disease.