However, mitophagy-related proteins such as PTEN-induced putative kinase 1 (PINK1) and Parkin were unchanged in RSL3-treated PARPi-resistant breast cancer cells (Figure 2D), indicating that RSL3 may induce non-selective autophagy, but not selective autophagy such as mitophagy. This evidence concerns the gene PRKN and breast carcinoma.