Concomitantly, performing transcriptional analysis to gain mechanistic insight into how MM cells suppress osteogenesis, we identified a set of extracellular matrix genes, i.e., ASPN, DPT, OGN, OMD, and MFAP4, that were consistently downregulated in MM-primed MSCs but upregulated during osteogenic differentiation. Here, OGN is linked to Miyoshi myopathy.