TTLL4 is commonly overexpressed in pancreatic cancer, and PELP1 polyglutamylation by TTLL4 may affect the composition or conformation of highly organized chromatin remodeling complexes like the MLL1-WDR5 complex and contribute to pancreatic cancer cell proliferation through histone modifications and chromatin remodeling [20]. Here, TTLL4 is linked to familial pancreatic carcinoma.