PELP1 modulates genes that are involved in the epithelial–mesenchymal transition (EMT), including MMPs, SNAIL (SNAI1), TWIST (TWIST1), ZEB (ZEB1), MYC, MTA1, miR-200a, and miR-141, leading to cancer metastasis progression [33,39,78,79]. The gene discussed is ZEB1; the disease is cancer.