In cancer, miR-483 acts as an oncogene by suppressing tumor-suppressive checkpoints across three functional axes: (i) cell-cycle acceleration coupled with apoptosis evasion; (ii) induction of EMT through Wnt/β-catenin and TGF-β/SMAD pathways; and (iii) amplification of growth-factor signaling and extracellular matrix remodeling that drive invasion and metastasis. This evidence concerns the gene TGFB1 and cancer.