In p53-wildtype cells, miR-483-3p suppression of MDM4 may enhance p53 activity and apoptosis, whereas in p53-mutant tumors, the same interaction becomes irrelevant, shifting the net effect of miR-483 toward oncogenicity via the repression of tumor suppressors like PTEN and SMAD4 [119]. This evidence concerns the gene MDM4 and neoplasm.