Under high-glucose conditions, O-linked N-acetylglucosamine transferase (OGT) further promotes this activation by stabilizing β-catenin and strengthening CTNNB1/USF1 binding to the miR-483 promoter, resulting in increased miR-483-3p expression and repression of the pro-apoptotic gene BBC3/PUMA, thereby contributing to tumor progression and chemoresistance, particularly in liver cancer [47]. This evidence concerns the gene BBC3 and liver cancer.