Seubert et al. demonstrated that TIMP-1 promotes hepatic PMN by a mechanism involving CXCL12α-mediated neutrophil recruitment and host-derived urokinase plasminogen activator (uPA), which mediates TIMP-1-triggered hepatocyte growth factor signaling and tumor cell dissemination throughout the liver parenchyma [88]. Here, TIMP1 is linked to neoplasm.