Due to increased ATP demand in cardiomyocytes, studies indicate that expression of the fatty acid transport protein CD36 and the key FAO enzyme carnitine palmitoyltransferase I (CPT1) is elevated, promoting FA uptake and oxidation [67]; thus, increased FAO is considered a core mechanism underlying RV hypertrophy in PAH [68,69,70]. This evidence concerns the gene CPT2 and pulmonary arterial hypertension.