TARDBP and amyotrophic lateral sclerosis: In larvae, the ALS model based on the overexpression of TAR DNA-binding protein-43 homologue (TBPH), the ortholog for human TDP-43, leads to excessive dendritic branching in sensory neurons C4da, while the downregulation reduces branching, demonstrating its critical role in neuronal morphogenesis via cell-autonomous mechanisms [60].