Emerging studies suggest that lipid rafts, critical membrane microdomains on tumor cell surfaces enriched with immune-related receptors such as PD-L1, CTLA-4, lymphocyte-activation gene 3 (LAG-3), T-cell immunoglobulin, and mucin domain-containing protein 3 (TIM-3), and signaling molecules, such as major histocompatibility complex class I (MHC-I), CD86, and CD47, play pivotal roles in immune cell activation, antigen recognition, immune synapse formation, and functional regulation of immune checkpoint molecules [8,9,10,11]. This evidence concerns the gene LAG3 and neoplasm.