HTR1A and Anxiety: Early clinical signals suggest that CBD may attenuate anxiety and agitation phenotypes, with acute anxiolytic effects demonstrated in simulated public speaking paradigms at 300–600 mg in adults and mechanistic links proposed via 5-HT1A, adenosinergic, and limbic network modulation; however, optimal dosing and durability remain unsettled, and sedation can emerge at higher doses [65,66].