Decreased reelin expression levels in the neocortex, entorhinal cortex, and hippocampus, combined with altered neurotransmitter receptor functions or impaired reelin signaling, were observed in humans suffering from a variety of different neurological disorders, including autism, schizophrenia, and Alzheimer’s disease [49,50,51,52,53,54]. The gene discussed is RELN; the disease is Alzheimer disease.