Stabilization of SIRT6 by USP48 prevents glycolytic shift and tumor progression [29], whereas dysregulation of non-coding RNAs, including Linc-smad7 and miR-338-3p, disrupts SIRT6 expression to promote proliferation, invasion, and chemoresistance [57,58] (Figure 3 and Table 1). The gene discussed is SIRT6; the disease is neoplasm.