SIRT6 and familial pancreatic carcinoma: Consistent with this view, multiple selective SIRT6 inhibitors, including allosteric modulators such as compound 11e and JYQ-42, as well as pyrrole-pyridinimidazole derivative 8a, have shown potent suppression of pancreatic cancer cell proliferation, invasion, and liver metastasis in vitro and in vivo [33,92].