This mechanism has been reported to be anecdotally effective in subclinical cases of ACTH-independent macronodular adrenal hyperplasia (AIMAH) associated with Cushing’s syndrome, as demonstrated by a case in which propranolol normalized serum and urinary cortisol levels by blocking ectopically expressed β-adrenergic receptors in the adrenal cortex [68]. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.