In ER-breast cancer, calycosin can up-regulate the expression of lncRNA WDR7-7 and decrease the G-protein coupled estrogen receptor 30 (GPR30) level in MDA-MB-468 and SKBR3 cell lines at the effective concentration of 4–16 μM, enabling it to inhibit cancer cell growth. Here, ESR1 is linked to breast carcinoma.