Regarding gastric cancer, in the N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced precancerous lesions of gastric carcinoma (PLGC) rats, calycosin down-regulates levels of NF-κB and DARPP-32, which enact the transformation of intestinal metaplasia and dysplasia, and STAT3, enabling it to protect against gastric injury at doses of 40 and 80 mg/kg [190]. Here, STAT3 is linked to gastric cancer.