NLRP3 and Sepsis: In a cecal ligation and puncture (CLP)-induced sepsis rat model, calycosin treatment was shown to decrease the levels of HMGB1, MyD88, p-NF-κB, and NLRP3, as well as the contents of pro-inflammatory cytokines such as TNF-α and IL-1β, at the significantly effective dose of 50 mg/kg [158].