In the Isoproterenol-induced myocardial infarction mice model, 40 mg/kg/day calycosin and 8 mg/kg/day gallic acid can reduce neutrophil infiltration and exhibit cardioprotective effects by synergistically inducing the expression of Leukotriene B4 12-hydroxydehydrogenase (LTB4DH) and reducing neutrophil-recruiting function of leukotriene B4 (LTB4) [48]. This evidence concerns the gene PTGR1 and myocardial infarction.