ADIPOQ and early-onset autosomal dominant Alzheimer disease: Independent studies further support the essential role of adiponectin signalling: peripheral inhibition of AdipoRs via ADP400 leads to a broad spectrum of deleterious effects, including increased β-amyloid accumulation in the hippocampus in Alzheimer’s disease models, heightened anxiety-like behaviour, impaired cognitive performance, and disrupted hippocampal neurogenesis [193].