TBXAS1 and hyperinsulinemic hypoglycemia, familial, 4: These are caused mainly by defects of the membrane receptors (Glanzmann thrombasthenia, P2Y12 deficiency, glycoprotein VI (GPVI) deficiency, among others), granules (Hermansky–Pudlak syndrome, among others), elements involved in signal transduction, or other defects of the biochemical platelet machinery (such as thromboxane A synthase 1 (TBXAS1) deficiency) [15].