HIF-1α intersects with multiple oncogenic signalling pathways relevant to melanoma progression, including PI3K–Akt–mTOR, RAS–RAF–MEK–ERK, Janus kinase (JAK)–STAT, Wnt–β-catenin, Notch, and NF-κB [125,126,127]. Here, NFKB1 is linked to melanoma.