TP53 and neoplasm: However, miR-124 suppresses tumors by inhibiting a crucial SASP regulator, STAT3 via targeting Bmi-1, a gene linked to stemness and SASP maintenance, miR-203 prevents tumor initiation and metastasis, while miR-125b affects senescence via controlling p53 and ERBB2, two factors that are implicated in the progression of SASP-associated tumors [93,94].