Considering that several anti-VISTA antibodies (e.g., CI-8993, HMBD-002, and KVA12123) are currently undergoing early-phase trials for solid tumors [144], both monotherapy and combination strategies with anti-PD-1/PD-L1 warrant investigation in epithelioid mesothelioma. Here, CD274 is linked to malignant epithelioid mesothelioma.