HIF1A and cancer: HIF1a signaling has previously been shown to promote metastasis in esophageal cancer [21] and NT5E a well-known target of HIF1a signaling in epithelial cells of other cancers [15,19,20] (Supplementary Table S1) [28], therefore we interrogated the relationship of HIF1a and NT5E regarding its expression and impact on survival in esophageal cancers.