Significant differences in the IHC marker expression among EMPD subgroups (primary, colonic, urothelial, and prostatic secondary EMPD) were observed for CDX2 (p < 0.001), CK7 (p < 0.001), CK20 (p < 0.001), GATA3 (p < 0.001), GCDFP15 (p < 0.001), p63 (p < 0.001), SATB2 (0.001), TRPS1 (p < 0.001), and uroplakin II/III (0.001) (Table 3). This evidence concerns the gene CDX2 and extramammary Paget disease.