We found that tumors such as bladder urothelial carcinoma (BLCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), esophageal cancer (ESCA), grade IV glioblastoma (GBM); cervical kidney renal papillary cell carcinoma (KIRP), sarcoma (SARC), and thymic carcinoma (THYM) showed upregulation of PARG, while in adrenocortical carcinoma (ACC), diffuse large B cell lymphoma (DLBC), acute myeloid leukemia (LAML), ovarian tumor (OV), and thyroid carcinoma (THCA), PARG isoforms are downregulated. The gene discussed is PARG; the disease is thyroid gland carcinoma.