PARP16 and neoplasm: Natural molecules like Epigallocatechin-3-gallate (EGCG), a polyphenol from green tea, have also proven effective in blocking tumor progression by inhibiting PARP7 and other MARTs, e.g., PARP16, blocking the unfolded protein response (UPR response) and endoplasmic reticulum stress, thereby inducing apoptosis in tumor cells (Figure 2) [74,75,76].