Data extracted from several databases, such as cBioPortal and the TCGA, demonstrate that PARP1, PARP3, PARP6, PARP7, PARP10, and PARP12 are overexpressed in various solid tumors, such as rectum adenocarcinoma (REAC), grade IV glioblastoma (GBM), breast cancer (TNBC), or mesothelioma (MESO); their expression is associated with malignancy and metastasis. The gene discussed is PARP3; the disease is glioblastoma.