However, other studies showed controversy in the published results and conclusions, given that Zhao et al. claimed that CRISPR/Cas9 silencing of PARP10 in HeLa cells increased invasion, cell migration, and metastasis in vivo, while maintaining levels of proliferation, colony formation, cell cycle, and apoptosis, indicating a tumor progression suppressor role in this model (Figure 2) [67]. This evidence concerns the gene PARP10 and neoplasm.