It describes abnormal activation of interferon signaling [84,85,86,87,88], induction of immunosuppressive SASP from senescent cells [89,90,91,92,93,94], upregulation of PD-L1 on tumor cells [97,98,99,100,101], and distinct effects on two antigen-presenting cell subpopulations and on MDSCs [102,103,104,105,106]. The gene discussed is CD274; the disease is neoplasm.