HER2 signalling can also crosstalk with the Wnt/β-catenin pathway; HER2 activation can stabilize β-catenin by inhibiting its degradation, leading to its nuclear translocation and transcriptional activation of Wnt target genes that drive proliferation, epithelial-to-mesenchymal transition (EMT), and tumour progression [23]. The gene discussed is ERBB2; the disease is neoplasm.