By contrast, Harkness et al. (2015) found a higher cumulative BC risk to age 70 in MLH1 carriers (18.6%; 95% CI, 11.3–25.9) versus both the UK general population (7.5–8%) and MSH2 carriers (11.2%; 95% CI, 1.4–21.0; p = 0.014) [155]. The gene discussed is MSH2; the disease is breast cancer.