MSH6 and breast cancer: In a population-based analysis, Roberts et al. reported statistically significant BC increases for MSH6 (SIR = 2.11; 95% CI, 1.56–2.86) and PMS2 (SIR = 2.92; 95% CI, 2.17–3.92), while MLH1 and MSH2 were not significantly associated with BC [154].