CD274 and bone metastasis: In these cases, at the time of diagnosis, brain metastases were present in 29/110 (26.4%) of patients, and bone metastasis in 35/110 (31.8%); in addition, PD-L1 expression analysis revealed that 68 patients had PD-L1 levels < 50%, while 39/107 (36.5%) patients had PD-L1 levels ≥ 50%.