Conversely, miR-200c shows a decreasing expression pattern from melanocytic nevi to primary melanomas and metastatic lesions, and restoring it significantly reduces cell proliferation, migration, and drug resistance by downregulating BMI-1, ABCG2, ABCG5, and MDR1, while increasing E-cadherin expression, effectively reversing aggressive melanoma phenotypes [73,74]. Here, CDH1 is linked to melanoma.