Tumor-suppressive miRNA regulation of stromal components is exemplified by miR-146a, which inhibits tumor-associated fibroblasts (TAFs) in colorectal cancer by targeting multiple inflammatory signaling intermediates, including TRAF6 (TNF receptor-associated factor 6), RIPK2 (receptor-interacting protein kinase 2), and PTGES2 (prostaglandin E synthase 2). This evidence concerns the gene PTGES2 and colorectal cancer.