miR-138-5p exemplifies miRNA-mediated enhancement of checkpoint inhibitor efficacy by directly targeting the 3′ untranslated region of PD-L1 (CD274) mRNA, resulting in a 67% reduction in luciferase reporter activity and significant downregulation of PD-L1 expression in A549 and Calu-6 adenocarcinoma cell lines [16]. The gene discussed is CD274; the disease is adenocarcinoma.