CTLA4 and lung adenocarcinoma: Similarly, exosome-mimetic nanovesicles carrying miR-200c sensitize lung adenocarcinoma to anti-CTLA-4 by targeting ZEB1, thereby restoring E-cadherin expression and promoting dendritic cell maturation and antigen cross-presentation, which yields complete tumor regression in 40% of treated mice and long-term immune memory upon rechallenge [123].