The copy number profile observed in ccfDNA mirrored that of the tumor, showing large chromosomal gains (1q, 7p, 8q, 9q, and 17q) and losses (6p and 9p), as well as focal deletions in the CDKN2A, SUZ12, and SMARCA2 genes associated with the transition from PN to ANNUBP. This evidence concerns the gene CDKN2A and neoplasm.