•Elevated in lung cancer patients, associated with reduced survival [171,172]•Can cause sarcopenia [173]•Increases INHBA expression, decreases PD-L1, and reduces anti-PD-L1 therapy [175]•INHBA inhibits Hipo to increase invasion [177]•INHBA is elevated in lung cancers and, when inhibited, decreases proliferation and improves therapy [180,181]•Can inhibit lung cancer proliferation and increase apoptosis [182]. The gene discussed is CD274; the disease is lung carcinoma.