NSUN2 and esophageal squamous cell carcinoma: Furthermore, numerous studies support role of NSUN2 as a tumor marker, as it is overexpressed in various cancers, including prostate, liver, stomach cancers, and esophageal squamous cell carcinoma [17,21,23,27], contributing to the promotion of malignant biological phenotypes such as metabolism, proliferation, invasion, immune response, cell death, and differentiation [16,44].