To further investigate the role of NSUN2 in tumor growth in NPC in vivo and to assess the contribution of TP53 to NSUN2-driven tumorigenesis, we injected stable CNE2 cell lines expressing shPLVX (control), shNSUN2, and shNSUN2 + shTP53 into the subcutaneous tissue of nude mice. Here, TP53 is linked to neoplasm.