CD8A and neoplasm: Oncolytic herpes simplex virus (oHSV) replication induces immunogenic tumor cell death and establishes a type-I interferon-rich microenvironment, leading to upregulation of major histocompatibility complex class I (MHC-I), promotion of CD8+ T-cell infiltration, and reduction in Treg and myeloid-derived suppressor cells (MDSC) burdens.