NFKB1 and neoplasm: Their cargo, which is enriched in pathogen-associated molecular patterns (PAMPs), activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, sustaining chronic inflammation, oxidative stress, and DNA damage, all of which contribute to tumor initiation and progression [13,14].